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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

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Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Polymeric nanoparticles for drug delivery.

Juliana M Chan1, Pedro M Valencia, Liangfang Zhang

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|March 11, 2010
PubMed
Summary
This summary is machine-generated.

Biodegradable polymeric nanoparticles (NPs) were developed for targeted cancer drug delivery. These NPs, functionalized with RNA aptamers, effectively bind to prostate cancer cells, showing potential for improved chemotherapy.

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08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Therapeutics

Background:

  • Biodegradable polymeric nanoparticles (NPs) offer promise for controlled drug delivery.
  • Targeted delivery systems are crucial for enhancing cancer treatment efficacy and reducing side effects.
  • Prostate cancer treatment can benefit from targeted therapies that specifically act on cancer cells.

Purpose of the Study:

  • To describe methods for preparing and characterizing drug-encapsulated biodegradable polymeric NPs.
  • To detail the surface functionalization of NPs with RNA aptamers targeting prostate-specific membrane antigen (PSMA).
  • To evaluate the binding capabilities of these targeted NPs to PSMA-expressing prostate cancer cells.

Main Methods:

  • Preparation and characterization of drug-loaded NPs using poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-b-PEG) copolymers.
  • Surface modification of NPs with A10 RNA aptamers for PSMA recognition.
  • In vitro and in vivo assessment of NP binding to PSMA-positive prostate cancer cells.

Main Results:

  • Successfully formulated and characterized drug-encapsulated PLGA-b-PEG NPs.
  • Achieved targeted functionalization of NPs with PSMA-specific RNA aptamers.
  • Demonstrated effective binding of targeted NPs to prostate cancer cells in vitro and in vivo.

Conclusions:

  • The described methods enable the development of targeted polymeric NPs for cancer therapy.
  • Functionalized NPs show specific binding to PSMA-expressing cells, indicating potential for targeted drug delivery.
  • These techniques can be extended to develop NPs for various therapeutic and diagnostic applications.