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Updated: Jun 15, 2026
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Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
Published on: December 29, 2015
[Viral noncoding RNAs].
Hiro-oki Iwakawa1, Testuro Okuno
1Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan. iwakawa@kais.kyoto-u.ac.jp
Uirusu
|March 12, 2010
Summary
Non-coding RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), regulate gene expression and host defense. Viruses utilize these non-coding RNAs to control viral proliferation and latency.
Area of Science:
- Molecular Biology
- Genetics
- Virology
Context:
- Non-coding RNAs (ncRNAs) are crucial regulators of gene expression in cellular processes.
- Viruses employ ncRNAs to manage their own gene expression and host interactions.
- Both host and viral ncRNAs play significant roles in biological systems.
Purpose:
- To review the generation mechanisms and functions of ncRNAs from DNA viruses.
- To introduce novel ncRNAs generated by animal and plant RNA viruses.
- To highlight the dual role of ncRNAs in host defense and viral propagation.
Summary:
- Recent evidence highlights the importance of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and small interfering RNAs (siRNAs), in gene expression and defense mechanisms.
- Viruses extensively utilize various types of ncRNAs to regulate their genomes and host cells, facilitating proliferation or latency.
- This review covers ncRNAs from DNA viruses and introduces novel ncRNAs originating from animal and plant RNA viruses, detailing their generation and functions.
Impact:
- Provides a comprehensive overview of viral non-coding RNAs.
- Enhances understanding of virus-host interactions at the molecular level.
- Identifies novel targets for antiviral strategies and therapeutic interventions.
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