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Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Helicobacter pullorum outbreak in C57BL/6NTac and C3H/HeNTac barrier-maintained mice
S R Boutin1, Z Shen, P L Roesch
1Taconic Inc., Hudson, New York 12534, USA.
Journal of Clinical Microbiology
|March 12, 2010
Summary
Helicobacter pullorum, a human bacterial pathogen, was successfully isolated from mice feces. This discovery enables further research into H. pullorum
Area of Science:
- Microbiology
- Bacteriology
- Infectious Diseases
Background:
- Helicobacter pullorum is recognized as a bacterial pathogen capable of causing human infections.
- Understanding the transmission and pathogenesis of H. pullorum is crucial for public health.
Purpose of the Study:
- To isolate and identify Helicobacter pullorum from a non-human source.
- To establish a potential animal model for studying H. pullorum pathogenesis.
Main Methods:
- Microaerobic culture techniques were employed for bacterial isolation.
- Biochemical analyses were performed for identification.
- Restriction fragment length polymorphism (RFLP) was used for genetic characterization.
- 16S rRNA gene sequencing confirmed bacterial identity.
Main Results:
- Helicobacter pullorum was successfully isolated from the feces of barrier-maintained mice.
- Comprehensive analyses confirmed the presence and identity of H. pullorum.
Conclusions:
- The isolation of H. pullorum from mice provides a novel opportunity to investigate its pathogenesis in a controlled animal model.
- This finding may facilitate the development of new strategies for preventing and treating H. pullorum infections.
