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Updated: Jun 15, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
The role of regulatory T cells in contact hypersensitivity
Tetsuya Honda1, Yoshiki Miyachi, Kenji Kabashima
1Department of Dermatology, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan.
Abstract:
Regulatory T cells (Tregs) are one of the T cell subsets that have strong immune-suppressive activity. Contact hypersensitivity (CHS), clinically manifested as contact dermatitis, is one of the most frequently used mouse models to address cutaneous immune responses, and is composed of two phases: sensitization and elicitation. Recently, the role of Tregs in CHS has been investigated using newly generated genetically engineered mice. In this review, we will provide an overview of recent patents and the mechanism of Treg-mediated immunosuppression especially in terms of IL-10, CD39, CTLA-4, and RANKL, and discuss the role of Tregs in CHS during the sensitization and elicitation phases.
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