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Updated: Jun 15, 2026

Acupuncture in a Rat Model of Asthma

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

Electroacupuncture promotes a decrease in inflammatory response associated with Th1/Th2 cytokines, nitric oxide and

E R Carneiro¹, R A N Xavier, M A Pedreira De Castro

¹Department of Physiology, Federal University of São Paulo (UNIFESP), São Paulo, SP, CEP: 09972-270, Brazil.

|March 17, 2010

Summary

Electroacupuncture (EA) therapy shows promise for asthma management. This study found EA balances Th1/Th2 responses, reducing inflammatory mediators like leukotriene B4 (LTB4) and nitric oxide (NO) in asthma models.

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Area of Science:

Immunology
Respiratory Medicine
Integrative Medicine

Background:

Asthma is a chronic respiratory disease characterized by airway inflammation.
Th2 cytokines, leukotriene B4 (LTB4), and nitric oxide (NO) are key mediators in asthma pathogenesis.
Electroacupuncture (EA) has previously demonstrated potential in reducing eosinophil infiltration in asthma models.

Purpose of the Study:

To investigate the effects of EA on Th2 cytokines, LTB4, and NO in an experimental asthma model.
To elucidate the anti-inflammatory mechanisms of EA in asthma.
To assess EA's impact on the Th1/Th2 immune balance.

Main Methods:

Male Wistar rats were divided into control, immobilized, sham acupuncture, and acupuncture groups.
EA was administered at clinical acupuncture points every other day for two weeks post-sensitization.
Cytokine production, LTB4, and NO levels in bronchoalveolar lavage (BAL) and pulmonary tissue (PT) were analyzed post-inhalation challenge.

Main Results:

EA significantly increased Interleukin-1 (IL-1) and Interferon-gamma (IFN-gamma).
EA decreased IL-4, IL-10, NO, and LTB4 levels in BAL and PT compared to control and sham groups.
Eosinophil presence in BAL negatively correlated with IL-1 and IFN-gamma, and positively with IL-4 and IL-10.

Conclusions:

EA exerts anti-inflammatory effects in asthma by modulating Th1/Th2 responses.
EA reduces key asthma mediators, including LTB4 and NO.
EA therapy may serve as a valuable complementary treatment for asthma.