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Related Concept Videos

The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The DNA Helix01:16

The DNA Helix

Overview
Chromatin Packaging01:32

Chromatin Packaging

Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
Chromatin Packaging02:21

Chromatin Packaging

Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

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DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

Covalently linked DNA nanotubes.

Ofer I Wilner1, Anja Henning, Bella Shlyahovsky

  • 1Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.

Nano Letters
|March 19, 2010
PubMed
Summary
This summary is machine-generated.

Researchers developed a method to create stable, covalently linked DNA nanotubes using functionalized circular DNA building blocks. These DNA nanostructures remain intact even when heated.

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Area of Science:

  • Nanotechnology
  • Molecular Biology
  • Materials Science

Background:

  • DNA nanotechnology offers precise control over nanoscale structure fabrication.
  • Developing stable and robust DNA nanostructures is crucial for various applications.
  • Covalent cross-linking enhances the stability of DNA-based nanomaterials.

Purpose of the Study:

  • To introduce a novel approach for preparing covalently linked DNA nanotubes.
  • To demonstrate the stability and integrity of the synthesized DNA nanostructures.

Main Methods:

  • Utilized circular DNA with thiol and amine functionalities as building blocks.
  • Employed sequential cross-linking with bis-amide-modified and bis-thiolated nucleic acids.
  • Investigated a one-step cross-linking method using tetra-amine functionalized DNA.

Main Results:

  • Successfully synthesized stable DNA nanotubes through covalent cross-linking.
  • Demonstrated that the resulting nanostructures are nonseparable upon heating.
  • Validated two distinct pathways for DNA nanotube formation.

Conclusions:

  • The developed method provides a reliable route to stable, covalently linked DNA nanotubes.
  • The enhanced stability opens possibilities for applications requiring robust DNA nanostructures.