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Surface-Modified Nanozymes for Enhanced and Selective Catalysis.

Xinghua Chen¹, Itamar Willner¹

¹Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

ACS Applied Materials & Interfaces

|July 23, 2025

Summary

This summary is machine-generated.

Surface-modified nanozymes (nanoparticle catalysts) offer improved performance over bare versions. Surface modifications enhance catalytic efficiency, selectivity, and biomembrane interactions for advanced applications.

Keywords:

Aptamer Chiroselectivity Molecular-imprinted polymer Nanomedicine Nanoparticle Reactive oxygen species (ROS)

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Area of Science:

Nanotechnology
Catalysis
Biochemistry

Background:

Bare nanozymes exhibit limitations like moderate catalytic turnovers and poor selectivity.
Challenges include substrate selectivity, chiroselectivity, and biomembrane permeability.

Purpose of the Study:

To review surface-modified nanozymes as hybrid frameworks.
To highlight improvements in catalytic properties and selective functions.
To discuss potential applications of these advanced nanomaterials.

Main Methods:

Functionalization of catalytic nanoparticles with aptamers, receptors (cyclodextrins), ligands (amino acids, peptides), and molecularly imprinted polymers.
Utilizing affinity interactions for substrate binding and concentration.
Molecular engineering of surface modifiers.

Main Results:

Surface modification enhances catalytic turnovers and substrate selectivity.
Achieved specific and chiroselective chemical transformations.
Introduced new catalytic functions not present in bare nanozymes.
Improved biomembrane interactions and permeability.

Conclusions:

Surface-modified nanozymes overcome limitations of bare counterparts.
Hybrid nanozymes offer superior catalytic efficiency, selectivity, and targeted delivery.
These engineered nanomaterials hold significant promise for diverse applications.