Related Experiment Video
Updated: Aug 18, 2026

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
[Transferrin receptors in squamous epithelial cancers of the head and neck]
1Zentrum der Hals-Nasen-Ohren-Heilkunde Universitätskliniken Frankfurt/Main.
Abstract:
Transferrin ist the transport protein of iron known to be an essential element of life. Iron transport crossing the cell membrane is mediated by the specific transferrin receptor (TR). However, the receptor was observed especially in proliferating tissues. We examined immunohistochemically the distribution pattern of this receptor in 60 squamous cell carcinomas of the head and neck. The results were correlated with their proliferative activities determined by the monoclonal antibody Ki67. All investigated tumors expressed the TR mostly distributed homogeneously with slight intra- and intertumorous differences. Generally with increasing expression of TR we could observe a decrease of the histopathological grading of the tumors investigated in our series. However, this relation could not be verified in all our cases. Therefore, only a semiquantitative analysis seemed to be reasonable. Our results indicate that the expression of TRs is not strongly associated to proliferative activity and cannot be used for measurements of growth fractions in squamous cell carcinomas.
More Related Videos
Related Concept Videos
lncRNA - Long Non-coding RNAs
The Early Endosome: Endocytosis of Transferrin
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...

