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Early bone changes in experimental osteoarthritis using microscopic computed tomography
D K Dedrick1, R Goulet, L Huston
1Department of Surgery, University of Michigan, Ann Arbor.
The Journal of Rheumatology. Supplement
|February 1, 1991
Abstract:
Alterations in trabecular subchondral bone have been measured using a microscopic computed tomography scanner in the guinea pig hind-limb myectomy model of osteoarthritis. These bone changes can be found as early as histologic changes in cartilage. To evaluate the influence of the myectomy on the animals, a gait study was performed. This data reveals an alteration in acceleration at the foot-flat phase of gait in the operated limb only, providing early quantification of the interaction between mechanics and biology.