Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

1.6K
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

2.1K
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
2.1K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma I: Introduction01:28

Asthma I: Introduction

112
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
112
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

49
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
49

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating inflammatory ILC2s as a biomarker of gastric cancer progression.

bioRxiv : the preprint server for biology·2026
Same author

Parasites trigger epithelial cell crosstalk to drive gut-brain signalling.

Nature·2026
Same author

Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches.

Science advances·2026
Same author

TSLP links intestinal nutrient sensing with amplification of the ILC2-tuft cell circuit.

Nature immunology·2025
Same author

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity.

Cell·2025
Same author

RORγt eTACs mediate oral tolerance and Treg induction.

The Journal of experimental medicine·2025
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

59.1K

Asthma and allergic inflammation.

Richard M Locksley1

  • 1Howard Hughes Medical Institute, University of California at San Francisco, 94143, USA. locksley@medicine.ucsf.edu

Cell
|March 23, 2010
PubMed
Summary
This summary is machine-generated.

Dysregulated interactions between airway epithelial cells and immune cells drive asthma and allergic inflammation. Similarities to responses against parasitic worms suggest new therapeutic pathways for these chronic inflammatory diseases.

More Related Videos

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.3K
Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

1.5K

Related Experiment Videos

Last Updated: May 3, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

59.1K
Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.3K
Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

1.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Allergy Research

Background:

  • Asthma and allergic inflammation involve complex interactions between mucosal epithelia and innate immune cells.
  • The increasing prevalence of these chronic inflammatory disorders necessitates understanding their underlying mechanisms.

Purpose of the Study:

  • To investigate the role of epithelial-immune cell interactions in asthma and allergic inflammation.
  • To explore potential therapeutic pathways by comparing these responses to those elicited by parasitic intestinal worms.

Main Methods:

  • Comparative analysis of immune responses in asthma models and parasitic worm infections.
  • Investigation of cellular signaling pathways at the mucosal barrier.

Main Results:

  • Dysregulated epithelial-innate immune cell interactions are central to asthma and allergic inflammation.
  • Shared pathways exist between mucosal responses to parasites and allergic diseases.

Conclusions:

  • Understanding the similarities between parasitic worm responses and allergic inflammation may offer novel therapeutic strategies.
  • Targeting epithelial-immune cell crosstalk presents a promising avenue for managing chronic inflammatory disorders.