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Association between reduced ADAMTS13 and diabetic nephropathy
Shotaro Taniguchi1, Teruto Hashiguchi, Tomoko Ono
1Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Thrombosis Research
|March 24, 2010
Summary
Reduced levels of ADAMTS13, an enzyme that cleaves von Willebrand factor, are linked to diabetic nephropathy progression. Lower ADAMTS13 antigen is associated with poorer kidney function and increased carotid intima-media thickness in type 2 diabetes patients.
Area of Science:
- Nephrology
- Endocrinology
- Hematology
Background:
- Von Willebrand factor (VWF)-cleaving protease (ADAMTS13) deficiency causes microcirculation thrombosis.
- Intrarenal coagulation is implicated in diabetic nephropathy development and progression.
Purpose of the Study:
- To investigate the association between plasma ADAMTS13 antigen (ADAMTS13Ag) levels and diabetic nephropathy.
- To explore the relationship between ADAMTS13Ag, renal function, and diabetic macroangiopathy.
Main Methods:
- Plasma VWF antigen (VWFAg) and ADAMTS13Ag levels were measured in 86 type 2 diabetic patients and 26 healthy volunteers.
- VWF/ADAMTS13 ratio was calculated to assess renal function and carotid intima-media thickness (IMT).
Main Results:
- ADAMTS13Ag showed a significant positive correlation with estimated glomerular filtration rate (eGFR) and a negative correlation with the VWF/ADAMTS13 ratio.
- ADAMTS13Ag levels were significantly lower in patients with overt nephropathy compared to healthy controls.
- Mean carotid IMT was negatively correlated with ADAMTS13Ag and positively correlated with the VWF/ADAMTS13 ratio.
Conclusions:
- Reduced ADAMTS13Ag levels are associated with impaired renal function and increased carotid IMT in type 2 diabetes.
- Lower ADAMTS13 levels may play a role in the pathogenesis of diabetic nephropathy and macroangiopathy.
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