Related Experiment Video
Updated: Jun 14, 2026

08:13
Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
Balance dysfunction in adults with haemophilia
1Preventive and Public Health Division, National Ageing Research Institute, Parkville, Vic., Australia. m.fearn@nari.unimelb.edu.au
Summary
People with haemophilia (PWH) show moderate impairments in balance and mobility, increasing falls risk. Assessments should include balance and related measures for adults with haemophilia.
Area of Science:
- Orthopedics
- Hematology
- Physical Therapy
Background:
- Lower limb physical performance in people with haemophilia (PWH) typically focuses on function, strength, and flexibility.
- The impact of haemophilic arthropathy on balance and falls risk remains under-explored.
Purpose of the Study:
- To evaluate balance and related performance in PWH compared to healthy controls.
- To identify potential links between haemophilic arthropathy and impaired balance or increased falls risk.
Main Methods:
- A comprehensive suite of clinical and laboratory measures assessed static and dynamic balance, mobility, strength, physical activity, and falls efficacy.
- Twenty PWH and 20 age- and gender-matched healthy controls participated in the study.
Main Results:
- Fifty percent of PWH reported falls in the past 12 months.
- PWH demonstrated moderate impairments in balance and related measures, with an average 35% difference compared to controls.
- Significant differences were found in dynamic balance, gait, mobility, muscle strength, and falls efficacy (P < 0.001).
Conclusions:
- Moderate impairments in balance, mobility, and related measures are present in PWH.
- Clinicians should incorporate balance and related assessments into routine reviews for adults with haemophilia to mitigate falls risk.
Related Concept Videos
Disorders of Hemostasis
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Homeostatic Imbalance
Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
However, sometimes these feedback loops fail,...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
