Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Upstream Processing01:27

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
Mechanical Systems01:22

Mechanical Systems

Mechanical systems are analogous to to electrical networks where springs and masses play similar roles to inductors and capacitors, respectively. A viscous damper in mechanical systems functions similarly to a resistor in electrical networks, dissipating energy. The forces acting on a mass in such systems include an applied force in the direction of motion, counteracted by forces from the spring, a viscous damper, and the mass's acceleration. This interplay of forces is mathematically described...
Bioreactor Controls-I01:28

Bioreactor Controls-I

Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...
Electro-mechanical Systems01:19

Electro-mechanical Systems

Electromechanical systems are intricate configurations that effectively combine electrical and mechanical elements to achieve a desired outcome. Central to many of these systems is the DC motor, a device that converts electrical energy into mechanical motion, enabling various applications ranging from simple fans to complex robotic mechanisms.
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell-Based Assays Using Derived Human-Induced Pluripotent Cells in Drug Discovery and Development.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Utility of Induced Pluripotent Stem Cell-Based Microphysiological Systems for Drug Development and Testing.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Evaluating the Effect of Drug Compounds on Cardiac Spheroids Using the Cardiac Cell Outgrowth Assay in a Microphysiological System.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Efficient separation of large particles and giant cancer cells using an isosceles trapezoidal spiral microchannel.

The Analyst·2024
Same author

In-line fiber optical sensor for detection of IgG aggregates in affinity chromatography.

Journal of chromatography. A·2024
Same author

A physiological model for iohexol plasma clearance supporting diagnostics of kidney function.

Clinica chimica acta; international journal of clinical chemistry·2024

Related Experiment Video

Updated: Jun 14, 2026

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
08:04

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

Mechatronics design principles for biotechnology product development.

Carl-Fredrik Mandenius1, Mats Björkman

  • 1Division of Biotechnology/IFM, Linköping University, S-581 83 Linköping, Sweden. cfm@ifm.liu.se

Trends in Biotechnology
|March 26, 2010
PubMed
Summary
This summary is machine-generated.

Biotechnology design is shifting towards mechatronic systems, integrating electronics, mechanics, and biology. This approach enhances the development of products like artificial organs and stem cell manufacturing.

More Related Videos

Application of Design Aspects in Uniaxial Loading Machine Development
05:23

Application of Design Aspects in Uniaxial Loading Machine Development

Published on: September 19, 2018

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Related Experiment Videos

Last Updated: Jun 14, 2026

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
08:04

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

Application of Design Aspects in Uniaxial Loading Machine Development
05:23

Application of Design Aspects in Uniaxial Loading Machine Development

Published on: September 19, 2018

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Area of Science:

  • Biotechnology Engineering
  • Mechatronics
  • Systems Integration

Background:

  • Traditional biotechnology design primarily focused on chemical and biologic manufacturing.
  • A significant portion of current biotechnology products result from mechatronic (mechanical-electric) engineering.
  • Biological components are integral to mechatronic systems, either as core parts or transformed entities.

Purpose of the Study:

  • To adapt mechanical engineering design principles for biotechnology product development.
  • To explore successful integration strategies for electronics, mechanics, and biology.
  • To identify emerging biotechnology areas benefiting from mechatronic design.

Main Methods:

  • Adapting established mechanical and production engineering design principles.
  • Analyzing the role of biological components within mechatronic systems.
  • Reviewing applications in stem cell manufacture, artificial organs, and bioreactors.

Main Results:

  • Demonstrated applicability of mechatronic design principles to biotechnology.
  • Highlighted successful integration of diverse engineering disciplines.
  • Identified key areas for future mechatronic biotechnology development.

Conclusions:

  • Mechatronic design principles offer a robust framework for modern biotechnology.
  • Successful integration of biology, electronics, and mechanics is crucial for innovation.
  • Emerging fields like stem cell technology and artificial organs are prime candidates for mechatronic approaches.