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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Jun 14, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

[Psoriasis].

Alexander A Navarini1, Ralph M Trüeb

  • 1Dermatologische Klinik, UniversitätsSpital Zürich.

Therapeutische Umschau. Revue Therapeutique
|March 26, 2010
PubMed
Summary
This summary is machine-generated.

Psoriasis is an autoimmune skin disease causing itchy, scaly plaques. Treatment varies by severity, from topical therapies for mild cases to systemic drugs and biologics for severe psoriasis.

Related Experiment Videos

Last Updated: Jun 14, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Context:

  • Psoriasis is a chronic, inflammatory skin condition with historical roots.
  • It is now understood as a systemic autoimmune disease.
  • Associated comorbidities significantly impact patient health.

Purpose:

  • To provide an overview of psoriasis, its characteristics, and current therapeutic strategies.
  • To highlight the factors influencing treatment decisions.
  • To underscore the importance of considering comorbidities and psychological impact.

Summary:

  • Psoriasis presents as inflammatory plaques with scaling, driven by epidermal hyperproliferation.
  • It's a T-cell mediated autoimmune disease affecting skin, nails, and joints.
  • Therapeutic approaches include anti-inflammatory, antiproliferative, and keratolytic agents.

Impact:

  • Understanding disease severity (PASI), quality of life (DLQI), and affected regions guides therapy.
  • Mild to moderate psoriasis often responds to topical treatments and phototherapy.
  • Severe cases require systemic agents like methotrexate or biologics, with attention to psychological and economic factors.