Related Experiment Video
Updated: Jun 14, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Paraproteinemia and renal diseases]
Anne-Pascale Grandjean1, Sarah Dettwiler, Patrick Saudan
1Service de médecine interne générale, HUG, 1211 Genève 14.
Revue Medicale Suisse
|March 30, 2010
Summary
Paraproteinemia, common in those over 50, often signals multiple myeloma with kidney damage. Early diagnosis and aggressive treatment, including chemotherapy and novel agents, are crucial to prevent kidney failure.
Area of Science:
- Nephrology
- Hematology
- Oncology
Context:
- Paraproteinemia is prevalent in individuals over 50.
- It frequently co-occurs with multiple myeloma, leading to various kidney complications.
Purpose:
- To highlight the association between paraproteinemia and renal involvement in multiple myeloma.
- To emphasize the need for prompt diagnosis and effective treatment strategies.
Summary:
- Multiple myeloma can cause kidney issues like cast nephropathy, light chain deposition disease, amyloidosis, and Fanconi syndrome.
- Treatment options include plasma exchange, high-cut-off filter dialysis, chemotherapy, and novel agents like bortezomib, thalidomide, and lenalidomide.
- Autologous hematopoietic stem cell transplantation is a standard treatment for eligible patients.
Impact:
- Timely intervention can prevent the progression to end-stage renal disease.
- Further research is needed to fully understand the efficacy of newer therapeutic agents in myeloma-associated kidney disease.
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