Related Experiment Video
Updated: Jun 14, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
Published on: August 12, 2019
Carbamoylation of aryl halides by molybdenum or tungsten carbonyl amine complexes
1Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Abstract:
When aryl halide is treated with molybdenum carbonyl amine complex in the presence of base, carbamoylation proceeds to give amide in good yield. The proposed mechanism involves oxidative addition of aryl halide to molybdenum(0) complex, migratory insertion to carbon monoxide giving acyl(amino)molybdenum(II) or aryl(carbamoyl)molybdenum(II) intermediate, and reductive elimination of the amide. This method is simple and provides an alternative method to the conventional palladium-catalyzed amide formation using gaseous carbon monoxide.
Related Concept Videos
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary amide...
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism
Nucleophilic Aromatic Substitution: Elimination–Addition
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
Reactions of α-Halocarbonyl Compounds: Nucleophilic Substitution
Preparation of Carboxylic Acids: Carboxylation of Grignard Reagents

