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Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models
Published on: April 26, 2024
Hypertension may affect tooth-supporting alveolar bone quality: a study in rats
Marta Ferreira Bastos1, Felipe Vilhena Brilhante, Tiago Eduardo Dias Gonçalves
1Department of Periodontics, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil. mfbastos@prof.ung.br
Journal of Periodontology
|March 31, 2010
Summary
Spontaneously hypertensive rats exhibit poor bone quality. Lercanidipine treatment for 45 days reduced bone resorption markers in these rats, suggesting a potential benefit for bone health.
Area of Science:
- Periodontology
- Bone Biology
- Pharmacology
Background:
- Spontaneously hypertensive rats (SHRs) are a model for studying hypertension-related health issues.
- Alveolar bone quality is crucial for tooth support and can be affected by systemic conditions.
Purpose of the Study:
- To evaluate ligature-induced bone loss and alveolar bone quality in SHRs.
- To assess the impact of lercanidipine on these parameters.
Main Methods:
- Histometric, histochemical, and immunohistochemical analyses were performed on Wistar rats and SHRs.
- Lercanidipine was administered daily to treated SHRs for 45 days.
- Bone loss, bone density, tartrate-resistant acid phosphatase (TRAP+), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG) were analyzed.
Main Results:
- No significant differences in bone loss or TRAP+ cells were observed in ligated teeth across groups.
- Increased bone loss and decreased bone density were noted around unligated teeth in both untreated and lercanidipine-treated SHRs.
- The untreated SHR group showed higher TRAP+ cells and RANKL/OPG+ ratio in unligated teeth compared to controls.
Conclusions:
- SHRs demonstrate detrimental alterations in tooth-supporting bone quality, irrespective of inflammation.
- Lercanidipine administration for 45 days led to decreased expression of bone resorption markers.
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