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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Related Experiment Video

Updated: Jun 14, 2026

Frailty Assessment in an Aging Mouse Model
06:58

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Published on: September 23, 2025

Impact papers on aging in 2009.

Mikhail V Blagosklonny1, Judy Campisi, David A Sinclair

  • 1Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA. Blagosklonny@oncotarget.com

Aging
|March 31, 2010
PubMed
Summary
This summary is machine-generated.

Research in 2009 highlights that aging is genetically regulated and not random. Key findings show interventions can decelerate aging, impacting longevity research.

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Area of Science:

  • Gerontology and Molecular Biology
  • Genetics and Longevity Research

Background:

  • Aging research in 2009 focused on significant impacts on lifespan.
  • Key areas included genetic influences, DNA repair, and telomere dynamics.

Purpose of the Study:

  • To review impactful aging research published in 2009.
  • To identify emerging themes in longevity and aging deceleration.

Main Methods:

  • Review of selected research papers from 2009.
  • Analysis of studies on genes, DNA damage, telomeres, calorie restriction, and pharmacological interventions.

Main Results:

  • Identified genes influencing aging acceleration and longevity in model organisms.
  • Explored molecular mechanisms behind lifespan extension through diet and drugs.
  • Highlighted the role of DNA damage responses and telomere maintenance.

Conclusions:

  • Aging is a genetically regulated process, not random.
  • Aging can be decelerated through genetic and pharmacological strategies.
  • A genetically-regulated longevity network is central to aging processes.