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Total synthesis of (+)-stachyflin: a potential anti-influenza A virus agent

Kazuhiro Watanabe1, Junji Sakurai, Hideki Abe

  • 1Laboratory of Synthetic Medicinal Chemistry, Department of Chemical Pharmaceutical Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, 981-8558, Aoba-ku, Sendai, Japan.

Chemical Communications (Cambridge, England)
|April 3, 2010
PubMed

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Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...