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Related Experiment Video

Updated: Jun 14, 2026

Silicon Microchips for Manipulating Cell-cell Interaction
23:21

Silicon Microchips for Manipulating Cell-cell Interaction

Published on: August 30, 2007

Controlling cellular activity by manipulating silicone surface roughness.

Babu R Prasad1, Michael A Brook, Terry Smith

  • 1National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.

Colloids and Surfaces. B, Biointerfaces
|April 6, 2010
PubMed
Summary
This summary is machine-generated.

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Increasing silicone surface roughness reduces fibroblast growth, potentially mitigating fibrous capsule formation around medical implants. Smoother surfaces, however, promote faster cell growth, offering new strategies for biomaterial design.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Surface Science

Background:

  • Silicone elastomers are widely used in biomaterials, but interface issues like fibrous capsule contracture in breast implants necessitate revision surgery.
  • The impact of surface topography on wound healing and subsequent capsule formation at silicone interfaces remains underexplored.

Purpose of the Study:

  • To investigate the relationship between silicone elastomer surface roughness and fibroblast (3T3) growth.
  • To determine if surface topography can be manipulated to control fibroblast proliferation and fibrous capsule formation.

Main Methods:

  • Silicone elastomer samples with varying root-mean-square (rms) surface roughness (88–650 nm) were prepared.
  • Fibroblast growth was quantified using the PicoGreen assay to measure DNA content.

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Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
08:02

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

Related Experiment Videos

Last Updated: Jun 14, 2026

Silicon Microchips for Manipulating Cell-cell Interaction
23:21

Silicon Microchips for Manipulating Cell-cell Interaction

Published on: August 30, 2007

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
08:02

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

  • Cell proliferation was compared across different roughness levels and a tissue culture plastic (TCP) control.

    • Main Results:

    • Fibroblast growth significantly decreased as surface roughness increased.
    • Smooth silicone (approx. 88 nm) showed twice the fibroblast DNA compared to rougher surfaces (approx. 378–650 nm).
    • While very rough silicone had fewer fibroblasts than TCP, smooth silicone surprisingly supported faster cell confluence.

    Conclusions:

    • Sub-micron surface roughness modification of silicone elastomers can modulate fibroblast growth.
    • Increasing surface roughness may be a viable strategy to reduce fibroblast proliferation and mitigate fibrous capsule formation on implants.
    • Surface topography plays a critical role in cell behavior at biomaterial interfaces.