Related Experiment Video
Updated: Jun 14, 2026
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
[Therapeutic effect of emodin in experimental periodonititis rats]
Bing Liu1, Shu-juan Li, Dong-ru Yang
1Department of Oral Medicine, The Stomatologic Hospital of Hebei Medical University, Shijiazhuang 050017, China. bingren1975@sina.com
Aim:
Through observing the change of Nitric Oxide (NO) in the peripheral blood and gingival tissue, to explore the mechanism of Emodin (EMD) in the therapy of periodontal disease.
Methods:
SD rats were randomly divided into four groups of thirty (group N, group P, group PL and the group PH). The periodontitis model was made and EMD was administered at PL and PH. At the 4th, 6th, 8th weeks after the animal models were established, the rats were killed respectively and the maxilla and the peripheral blood were collected. A side of maxilla was stained with HE for histological examination and the other side of gingival tissue surround ligated tooth was collected for the measurement of NO. Also, it was measured in the peripheral blood. GLM method using SPSS was used to compare changes in each of the variables over time.
Results:
The levels of NO in the peripheral blood and gingival tissue in PL and PH groups were significantly lower than that in P groups(P<0.05).
Conclusion:
Emodin can take effect on periodontitis by reducing the levels of NO in the peripheral blood and gingival tissue.