The updated view concerning the possibility of growing old without senescence

New findings paradoxically highlight the capability of old mitochondria, precursor cells, tissues, and organs for rejuvenation during vital activity at appropriate conditions and modes. But most studies of aging are conducted in living beings situated in rather artificial conditions. Such external conditions are less adequate to the evolutionarily adjusted genetic construction of an organism and lead to the appearance of senescence due to incomplete self-maintenance processes. These arguments as well as other findings suggest that imitation of appropriate external signals or peculiar modification of control systems of an organism can lead to the state of full nonsenescence.