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Sequential synthesis of (E)-alpha,beta-unsaturated primary amides with complete stereoselectivity

José M Concellón1, Humberto Rodríguez-Solla, Carmen Concellón

  • 1Departamento de Química Organica e Inorgánica, Facultad de Química, Universidad de Oviedo, Spain. jmcg@uniovi.es

The Journal of Organic Chemistry
|April 10, 2010
PubMed
Summary

A new method efficiently synthesizes (E)-alpha,beta-unsaturated primary amides. This stereoselective process uses a samarium diiodide-mediated reaction with aldehydes, followed by beta-elimination.

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