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Oligosaccharides from agar inhibit pro-inflammatory mediator release by inducing heme oxygenase 1
Tatsuji Enoki1, Shinji Okuda, Yoko Kudo
1Biotechnology Research Laboratories, Takara Bio Inc., Otsu, Shiga, Japan. enokit@takara-bio.co.jp
Abstract:
We investigated whether agaro-oligosaccharides have any immunological effects on RAW264.7 mouse macrophages and human monocytes in vitro. We demonstrate that agaro-oligosaccharides suppressed the elevated levels of nitric oxide, prostaglandin E(2), and such pro-inflammatory cytokines as tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in lipopolysaccharide-stimulated monocytes and macrophages. We also demonstrate that those effects of agaro-oligosaccharides on activated monocytes and macrophages may have been caused by heme oxygenase-1 induction. It is therefore proposed that agaro-oligosaccharides might be a good candidate for a functional food to prevent inflammatory diseases.
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