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Updated: Jun 14, 2026
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Aortic Customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using
W M P F Bosman1, J Vlot, T J van der Steenhoven
1Department of Surgery, Leiden University Medical Center, Post box 9600, K6-R, 2300 RC Leiden, The Netherlands. w.m.p.f.bosman@lumc.nl
Objective:
This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model.
Design:
Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created.
Material:
The formulation used in the experiments consisted of a two-component addition-cure liquid-silicone formulation, based on vinyl-terminated polydimethylsiloxane (PDMS).
Methods:
The concept of aneurysm-sac filling was tested in vivo in porcine experiments (n = 3).
Results:
In vivo porcine experiments with the sac-filling application showed successful exclusion of the created aneurysms with patent lumens and absence of endoleaks. The aneurysms were excluded successfully in the in vivo model, injecting elastomer through a 7-French catheter, filling up the entire aneurysm sac.
Conclusions:
These in vivo experiments demonstrate that the principle of aneurysm-sac filling by means of in situ curing is feasible, excluding the aneurysm and creating a new lumen. Further long-term animal experiments must be done prior to consideration of clinical application.
