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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
FAM5C contributes to aggressive periodontitis
Flavia M Carvalho1, Eduardo M B Tinoco, Kathleen Deeley
1Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Plos One
|April 13, 2010
Summary
Aggressive periodontitis involves rapid gum destruction. Researchers found the FAM5C gene is associated with this condition and its expression increases with disease severity, suggesting it plays a role in aggressive periodontitis.
Area of Science:
- Genetics
- Periodontology
- Immunology
Background:
- Aggressive periodontitis is a severe gum disease affecting young individuals, with higher prevalence in certain ethnic groups.
- The genetic underpinnings of aggressive periodontitis are not fully understood, necessitating further investigation into potential genetic loci and contributing factors.
Purpose of the Study:
- To fine-map the 1q24.2-1q31.3 chromosomal region for aggressive periodontitis susceptibility loci.
- To investigate the role of the FAM5C gene in the pathogenesis of aggressive periodontitis.
- To analyze FAM5C expression levels in diseased periodontal tissues and their correlation with inflammatory markers.
Main Methods:
- Genotyping of 21 single nucleotide polymorphisms (SNPs) in 389 subjects from 55 pedigrees.
- Non-parametric linkage and transmission disequilibrium tests were performed.
- Quantitative analysis of FAM5C mRNA expression in healthy and diseased periodontal tissues, correlated with inflammatory cytokine mRNA levels (IL-1beta, IL-17A, IL-4, RANKL).
Main Results:
- A significant association was found between aggressive periodontitis and two SNPs (rs1935881, rs1342913) in the FAM5C gene (p=0.03).
- Haplotype analysis confirmed the association with the A-G haplotype (rs1935881-rs1342913; p=0.009).
- FAM5C mRNA expression was significantly elevated in aggressive periodontitis lesions and correlated positively with IL-1beta, IL-17A, IL-4, and RANKL mRNA levels.
Conclusions:
- The FAM5C gene is implicated in the development of aggressive periodontitis.
- Increased FAM5C expression in diseased sites suggests a role in the inflammatory processes characteristic of aggressive periodontitis.
- FAM5C's contribution to aggressive periodontitis appears independent of common periodontal pathogens like 'red complex' bacteria or Aggregatibacter actinomycetemcomitans.
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