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Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Mismatch Repair01:36

Mismatch Repair

Overview
Mismatch Repair01:36

Mismatch Repair

Overview
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...

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Related Experiment Video

Updated: Jun 13, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Omission mismatch negativity builds up late.

János Horváth1, Dagmar Müller, Annekathrin Weise

  • 1Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary. horvath@cogpsyphy.hu

Neuroreport
|April 14, 2010
PubMed
Summary

Mismatch negativity (MMN) event-related potentials (ERPs) build up rapidly. However, omission-related ERPs require more frequent omissions to emerge, indicating a slower build-up compared to MMN.

Related Experiment Videos

Last Updated: Jun 13, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Area of Science:

  • Auditory Neuroscience
  • Cognitive Neuroscience
  • Neuroscience

Background:

  • Mismatch negativity (MMN) is an event-related potential (ERP) reflecting auditory change detection.
  • MMN generation is influenced by the duration of preceding regular auditory stimulation, showing rapid build-up.
  • Infrequent auditory omissions can also elicit MMN-like waveforms, prompting investigation into their build-up characteristics.

Purpose of the Study:

  • To investigate the build-up process of omission-related event-related potentials (ERPs).
  • To compare the build-up speed of omission-related ERPs with that of mismatch negativity (MMN).

Main Methods:

  • Presentation of auditory sequences with omissions at penultimate stimulus positions.
  • Varying the number of preceding tones (two to nine) in repetitive sequences.
  • Introducing omissions with a 9% probability within continuously presented tones.

Main Results:

  • No consistent omission-related ERP was observed when omissions occurred after short trains of tones.
  • An omission-related waveform was elicited when omissions occurred with a 9% probability among continuous tones.
  • These findings suggest a difference in the build-up dynamics between MMN and omission-related ERPs.

Conclusions:

  • The build-up of omission-related ERPs is slower than that of mismatch negativity (MMN).
  • Auditory change detection mechanisms may differ in their sensitivity to regularity and omission patterns.
  • Further research is needed to fully elucidate the neural processes underlying omission detection.