[Pathogens distribution and drug sensitivity of infantile dacryocystitis]

Hong Sun1, Jiang-yue Zhao, Qi-chang Yan

  • 1Department of Ophthalmology, Shenyang Children's Hospital, Shenyang 110032, China.

Insights

Coagulase-negative staphylococcus is the primary pathogen causing infantile dacryocystitis. This study identified common bacterial culprits and their drug sensitivities to guide effective treatment strategies for infant eye infections.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Context:

  • Infantile dacryocystitis is a common condition affecting newborns.
  • Accurate identification of pathogens and their antibiotic susceptibility is crucial for effective treatment.

Purpose:

  • To identify the causative pathogens in infantile dacryocystitis.
  • To determine the drug resistance patterns of these pathogens.
  • To provide evidence-based recommendations for clinical drug use in treating infantile dacryocystitis.

Summary:

  • A study analyzed 230 infant dacryocystitis cases, identifying bacterial pathogens and their drug sensitivities.
  • Gram-positive cocci, particularly coagulase-negative staphylococcus, were the predominant pathogens.
  • Most isolates showed sensitivity to tobramycin, ciprofloxacin, and levofloxacin, while resistance to erythromycin and penicillin was noted.

Impact:

  • Findings guide the selection of appropriate antibiotics for infantile dacryocystitis, potentially improving treatment outcomes.
  • Highlights the prevalence of specific pathogens, aiding in targeted therapeutic approaches.
  • Contributes to understanding antimicrobial resistance patterns in pediatric eye infections.
Abstract

Related Concept Videos

Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...