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Published on: July 24, 2016
[Pathogens distribution and drug sensitivity of infantile dacryocystitis]
Hong Sun1, Jiang-yue Zhao, Qi-chang Yan
1Department of Ophthalmology, Shenyang Children's Hospital, Shenyang 110032, China.
Insights
Coagulase-negative staphylococcus is the primary pathogen causing infantile dacryocystitis. This study identified common bacterial culprits and their drug sensitivities to guide effective treatment strategies for infant eye infections.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Context:
- Infantile dacryocystitis is a common condition affecting newborns.
- Accurate identification of pathogens and their antibiotic susceptibility is crucial for effective treatment.
Purpose:
- To identify the causative pathogens in infantile dacryocystitis.
- To determine the drug resistance patterns of these pathogens.
- To provide evidence-based recommendations for clinical drug use in treating infantile dacryocystitis.
Summary:
- A study analyzed 230 infant dacryocystitis cases, identifying bacterial pathogens and their drug sensitivities.
- Gram-positive cocci, particularly coagulase-negative staphylococcus, were the predominant pathogens.
- Most isolates showed sensitivity to tobramycin, ciprofloxacin, and levofloxacin, while resistance to erythromycin and penicillin was noted.
Impact:
- Findings guide the selection of appropriate antibiotics for infantile dacryocystitis, potentially improving treatment outcomes.
- Highlights the prevalence of specific pathogens, aiding in targeted therapeutic approaches.
- Contributes to understanding antimicrobial resistance patterns in pediatric eye infections.
Objective:
To investigate the pathogens and drug tolerance of infantile dacryocystitis in order to provide evidence for clinical drug use.
Methods:
230 cases of infant dacryocystitis (aged from 2 to 10 months, average 90 days) were analyzed for bacterial culture and drug sensitivity tests. These tests were performed following National Guide to Clinical Laboratory Procedures. Based on the results, analyzed the difference of pathogens in different year, the pathogens kind of dacryocystitis, main pathogens of infantile dacryocystitis, average isolation rate of pathogens and sensitive or resistance drug for pathogens.
Results:
Average detecting rate was 87.0% (200 cases). There is no difference for detecting rate in each year. The pathogens were predominantly gram-positive coccus 74.5% (149 cases), coagulase-negative staphylococcus 20.5% (41 cases) and staphylococcus aureus 11.0% (22 cases). Majority of these bacteria were sensitive to tobramycin, ciprofloxacin and levofloxacin. Gram-positive coccus was sensitive to tobramycin and levofloxacin. For gram-negative rod, tobramycin and chloromycetin were most sensitive drug. The sensitivity rates were 96.67% (29 cases). The resistant rates to erythromycin and penicillin were 66.67% (20 cases) and 80.00% (24 cases).
Conclusion:
Coagulase-negative staphylococcus was the main pathogen of infantile dacryocystitis.
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