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Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
Two diketopiperazines from Acanthopanax senticosus Harms
Zhi-Feng Li1, Nan Xu, Bao-Min Feng
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Journal of Asian Natural Products Research
|April 15, 2010
Summary
Two new diketopiperazines, eleutherazines A and B, were discovered in Acanthopanax senticosus. Their chemical structures were identified using advanced spectroscopic and chemical analysis methods.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- Acanthopanax senticosus is a plant used in traditional medicine.
- Diketopiperazines are a class of alkaloids with diverse biological activities.
- The chemical constituents of A. senticosus are not fully explored.
Purpose of the Study:
- To isolate and characterize new compounds from Acanthopanax senticosus.
- To elucidate the structures of novel diketopiperazines.
Main Methods:
- Extraction of dried aerial parts of Acanthopanax senticosus.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using spectroscopic methods (NMR, MS) and chemical analysis.
Main Results:
- Two new diketopiperazines, named eleutherazines A (1) and B (2), were isolated.
- The chemical structures of eleutherazines A and B were successfully determined.
Conclusions:
- Acanthopanax senticosus contains novel diketopiperazine compounds.
- Eleutherazines A and B represent new additions to the known natural products from this plant species.
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