Related Experiment Video
Updated: Jun 13, 2026
07:50
2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum
Published on: December 8, 2023
Two new xanthones from Artocarpus obtusus
Najihah Hashim1, Mawardi Rahmani, Mohd A Sukari
1Department of Chemistry, Universiti Putra Malaysia 43400 UPM, Selangor, Malaysia.
Journal of Asian Natural Products Research
|April 15, 2010
Summary
Two new xanthones were discovered in Artocarpus obtusus stem bark. One xanthone demonstrated significant free radical scavenging and cancer cell cytotoxicity.
Area of Science:
- Natural Product Chemistry
- Pharmacognosy
- Medicinal Chemistry
Background:
- The stem bark of Artocarpus species is a rich source of bioactive compounds.
- Xanthones are a class of natural products with diverse pharmacological activities.
Purpose of the Study:
- To isolate and characterize new xanthone compounds from Artocarpus obtusus stem bark.
- To evaluate the biological activities of the isolated compounds, including antioxidant and cytotoxic effects.
Main Methods:
- Chromatographic separation techniques were employed for isolation.
- Spectroscopic methods (e.g., NMR, MS) were used for structure elucidation.
- DPPH assay was used to assess free radical scavenging activity.
- Cytotoxicity was evaluated against K562, HL-60, and MCF7 cancer cell lines.
Main Results:
- Two novel xanthones, pyranocycloartobiloxanthone A (1) and dihydroartoindonesianin C (2), were successfully isolated and identified.
- Pyranocycloartobiloxanthone A (1) exhibited potent free radical scavenging activity.
- Compound 1 also displayed significant cytotoxicity against K562, HL-60, and MCF7 cell lines.
Conclusions:
- Artocarpus obtusus stem bark is a source of new xanthone derivatives.
- Pyranocycloartobiloxanthone A possesses promising antioxidant and anticancer properties.
- Further research into these compounds may lead to the development of new therapeutic agents.
Related Concept Videos
01:58Fruit Development, Structure, and Function
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
01:14Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
Electrophilic addition of halogens to alkenes proceeds via a cyclic halonium ion to form a 1,2-dihalide or a vicinal dihalide.
02:23Autoxidation of Ethers to Peroxides and Hydroperoxides
Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.