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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Antioxidant flavonoids from Alhagi maurorum
Saeed Ahmad1, Naheed Riaz, Muhammad Saleem
1Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, Railway Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. rsahmed_iub@yahoo.com
Journal of Asian Natural Products Research
|April 15, 2010
Summary
Researchers isolated three flavonoids from Alhagi maurorum, including a new compound. Two of these flavonoids demonstrated moderate antioxidant activity in free radical scavenging assays.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Medicinal Plant Research
Background:
- Alhagi maurorum is a plant with a history of traditional use.
- Flavonoids are a class of plant secondary metabolites known for diverse biological activities.
Purpose of the Study:
- To isolate and characterize chemical constituents from Alhagi maurorum.
- To evaluate the antioxidant potential of the isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy (1D and 2D).
- Antioxidant activity assessment using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay.
Main Results:
- A new flavonoid, isorhamnetin-3-O-[-alpha-l-rhamnopyranosyl-(1 --> 3)]-beta-D-glucopyranoside (1), was identified.
- Two known flavonoids, 3'-O-methylorobol (2) and quercetin 3-O-beta-d-glucopyranoside (3), were also isolated and characterized.
- Compounds 1 and 2 exhibited moderate antioxidant activity against DPPH free radicals.
Conclusions:
- The phytochemical investigation of Alhagi maurorum led to the identification of novel and known flavonoid compounds.
- The isolated flavonoids, particularly compounds 1 and 2, possess notable antioxidant properties, suggesting potential therapeutic applications.
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