Two new steroidal alkaloids from the roots of Sarcococca ruscifolia

Two new steroidal alkaloids, 20alpha-dimethylamino-2alpha-hydroxyl-3beta-tigloylamino-5alpha-pregnane (1) and Delta(16)-20alpha-dimethylamino-3beta,4alpha-diol-5alpha-pregnane (2), along with five known alkaloids, sarcovagine D (3), pachysamine G (4), pachysamine H (5), pachysamine A (6), and terminaline (20S)-20-(N,N-dimethylamino)-5alpha-pregn-3beta,4alpha-diol (7), were isolated from the roots of Sarcococca ruscifolia. Their structures were elucidated on the basis of NMR and MS data, and the relative stereochemistry of 1 was finally determined by X-ray crystallographic analysis.