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Plasma cortisol concentrations after CIDR insertion in beef cows.

S T Long1, N C Thinh, M Yusuf

  • 1Laboratory of Theriogenology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan.

Reproduction in Domestic Animals = Zuchthygiene
|April 21, 2010
PubMed
Summary

Controlled internal drug release (CIDR) devices significantly increase plasma cortisol concentrations in beef cows. This study measured cortisol levels before, during, and after CIDR insertion in cows.

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Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Animal Reproduction

Background:

  • Controlled internal drug release (CIDR) devices are used in cattle reproduction.
  • The physiological effects of CIDR insertion on stress hormones like cortisol are not fully understood.

Purpose of the Study:

  • To investigate the impact of intra-vaginal CIDR devices on plasma cortisol concentrations in non-suckling beef cows.
  • To quantify changes in cortisol levels following CIDR insertion and removal.

Main Methods:

  • Two groups of beef cows were used, with crossover treatment and control periods.
  • Plasma samples were collected at various time points relative to CIDR insertion.
  • Cortisol concentrations were analyzed using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • A statistically significant increase (p<0.01) in plasma cortisol concentrations was observed after CIDR insertion.
  • Mean cortisol levels rose from a baseline of 1.3 ± 0.4 ng/ml to a peak of 8.8 ± 1.1 ng/ml at 5 hours post-insertion.
  • Cortisol levels returned to basal concentrations within 7 hours after device removal.

Conclusions:

  • Intra-vaginal device insertion, specifically CIDR, induces a transient increase in plasma cortisol in beef cows.
  • The clinical or pathophysiological significance of this cortisol elevation requires further investigation.