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Updated: Jun 13, 2026
Human Blastocyst Biopsy and Vitrification
Published on: July 26, 2019
Defragmentation of low grade day 3 embryos resulted in sustained reduction in fragmentation, but did not improve
Martin Keltz1, Rani Fritz, Eric Gonzales
1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, St. Luke's Roosevelt Hospital Center, Columbia University College Of Physicians and Surgeons, New York, New York 10019, USA. mdkeltz@aol.com
Abstract:
In a prospective randomized fashion, this study evaluated embryo development in vitro after defragmentation versus assisted hatching alone of low grade day 3 embryos. Although a sustained decrease in day 5 fragmentation was observed in the defragmented group versus the assisted hatching only group, no difference in compaction rates or blastula formation rates were appreciated.
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