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Evaluation and management of B and T cell abnormalities
1Texas Children's Hospital, Department of Allergy/Immunology, Houston 77030.
Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|January 1, 1991
Summary
This review covers common congenital lymphocyte deficiencies, including B cell disorders like X-linked agammaglobulinemia and T cell defects such as Di-George syndrome and severe combined immunodeficiency, alongside HIV/AIDS.
Area of Science:
- Immunology
- Genetics
- Pediatrics
Background:
- Congenital lymphocyte deficiencies stem from genetic or developmental abnormalities.
- These complex conditions affect the immune system's B and T cell functions.
- Common prototypes are highlighted for clarity.
Purpose of the Study:
- To discuss common congenital deficiencies of the lymphocyte system.
- To review B cell and T cell defects.
- To briefly address HIV infection and AIDS.
Main Methods:
- Review of common congenital lymphocyte deficiencies.
- Discussion of B cell diseases: X-linked agammaglobulinemia, selective IgA deficiency, IgG subclass deficiency, common variable immunodeficiency.
- Discussion of T cell defects: Di-George syndrome, severe combined immunodeficiency.
Main Results:
- Identified and categorized common B cell and T cell deficiencies.
- Included brief mention of HIV infection and AIDS as related immune issues.
- Considered diagnostic evaluation and general treatment principles.
Conclusions:
- Congenital lymphocyte deficiencies are diverse, impacting B and T cell immunity.
- Understanding these prototypes aids in diagnosis and management.
- Further research and awareness are crucial for HIV/AIDS and related immunodeficiencies.