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Update on urticaria and angioedema (hives)
1Division of Allergy and Immunology, University of South Florida Health Sciences Center, Tampa, USA.
Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|November 1, 1995
Summary
New research explores severe chronic hives (urticaria) unresponsive to standard treatments. A specific autoantibody (IgG against IgE receptor) is identified, leading to increased use of immunomodulating agents for better patient outcomes.
Area of Science:
- Immunology
- Dermatology
Background:
- Urticaria is a common skin condition.
- Severe chronic urticaria often resists conventional therapies.
Purpose of the Study:
- To update on new concepts in urticaria pathogenesis.
- To review novel treatments for severe, refractory hives.
Main Methods:
- Literature review of recent advancements.
- Identification of novel autoantibodies.
- Analysis of emerging treatment strategies.
Main Results:
- A novel autoantibody, IgG against the IgE receptor, is identified in some severe chronic urticaria patients.
- Anti-inflammatory and immunomodulating agents show promise.
Conclusions:
- Understanding of urticaria pathogenesis is evolving.
- New therapeutic approaches are emerging for difficult-to-treat chronic idiopathic urticaria (CIU).