Related Experiment Video
Updated: Jun 13, 2026

Analysis of Immune Cells in Single Sciatic Nerves and Dorsal Root Ganglion from a Single Mouse Using Flow Cytometry
Published on: December 6, 2017
Molecular inflammatory mediators in peripheral nerve degeneration and regeneration
Carlos Rodrigo Cámara-Lemarroy1, Francisco Javier Guzmán-de la Garza, Nancy Esthela Fernández-Garza
1Department of Physiology, Universidad Autónoma de Nuevo León, School of Medicine, Monterrey, Mexico. crcamara83@hotmail.com
Abstract:
Wallerian degeneration, the self-destructive set of cellular and molecular processes by which degenerating axons and myelin are cleared after injury, is initiated by macrophages and Schwann cells. Molecular inflammatory mediators such as cytokines (IL-1, IL-6, IL-10, and TNF-alpha, among others), transcription factors (NF-kappaB, c-Jun), the complement system and arachidonic acid metabolites have been shown to modulate these processes in various studies. However, the exact role that each of these mediators plays during axonal degeneration and regeneration has not been fully established. Understanding the molecular basis of these interactions between the immune system and peripheral nerve injury would open the possibility of targeting these inflammatory mediators as therapeutic interventions. In this review we attempt to integrate the current evidence generated around this issue, and to explore the therapeutic possibilities that arise.
Related Concept Videos
Neurogenesis and Regeneration of Nervous Tissue
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Nociception
Acute Inflammation III: Local and Systemic Effects
Acute Inflammation I: Inflammatory Response
Degenerative Disc Disease ll: Pathophysiology
