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Surface analysis of surface-passivated intraocular lenses
D D Koch1, S W Samuelson, V Dimonie
1Cullen Eye Institute, Houston, Texas 77030.
Journal of Cataract and Refractive Surgery
|March 1, 1991
Summary
Surface analysis of poly(methyl methacrylate) intraocular lenses revealed significant differences in chemical composition and surface energy. Polyfluorocarbon-coated and polyvinylpyrrolidone-grafted lenses showed distinct surface properties compared to other types.
Area of Science:
- Ophthalmology
- Materials Science
- Surface Chemistry
Background:
- Poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) are widely used.
- Surface properties of IOLs can influence biocompatibility and clinical outcomes.
- Variations in manufacturing processes may lead to differences in IOL surface characteristics.
Purpose of the Study:
- To characterize and compare the surface chemistry and energy of six different types of PMMA IOLs.
- To identify potential surface contaminants and their distribution across various IOL manufacturing methods.
Main Methods:
- Electron Spectroscopy for Chemical Analysis (ESCA) to determine surface elemental composition.
- Static Secondary Ion Mass Spectroscopy (SIMS) to detect surface contaminants like siloxanes.
- Contact angle measurements and surface energy calculations to assess surface wettability and energy.
Main Results:
- ESCA showed distinct surface compositions for polyfluorocarbon-coated and polyvinylpyrrolidone-grafted IOLs.
- Siloxane contaminants were detected on lathe-cut and cast-molded IOLs, with lower levels on surface-passivated IOLs.
- Polyfluorocarbon-coated IOLs exhibited lower surface energies, while polyvinylpyrrolidone-grafted IOLs had higher surface energies.
Conclusions:
- Manufacturing methods significantly impact the surface properties of PMMA IOLs.
- Surface-passivation techniques may reduce siloxane contamination in lathe-cut IOLs.
- Tailoring surface chemistry and energy of IOLs is crucial for optimizing performance.