Novel mathematical model for predicting the dissolution profile of spherical particles under non-sink conditions
Yasuyoshi Agata1, Yasunori Iwao, Atsuo Miyagishima
1School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.
Abstract:
A mechanistic mathematical model was designed to predict dissolution patterns under non-sink conditions. Sulfamethoxazole was used as a model drug, and its physico-chemical properties such as solubility, density, and intrinsic dissolution rate constant etc., were investigated in order to apply these experimental values to the proposed model. Dissolution tests were employed as a way of validating the mathematical model, and it was found that the predictions given by the model were surprisingly accurate for all particle sizes. In addition, a simulation focused on forecasting the fraction of the drug that was dissolved at a certain time point when various initial particle diameters were used was also particularly valuable. Therefore, these results demonstrated that the model enables dissolution profiles to be analyzed under non-sink conditions.
Related Concept Videos
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Factors Affecting Dissolution: Particle Size and Effective Surface Area
In Vitro Drug Dissolution: Compendial Testing Models I
Drug Dissolution: Requirements and Profile Comparison
In Vitro Drug Dissolution: Alternative Methods

