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Updated: Jun 13, 2026

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
Published on: May 30, 2012
[The dual role of OCT4]
Sonia Stefanovic1, Michel Pucéat
1Inserm UMR 633, Université Paris Descartes, programme Avenir, Equipe Cellules souches et cardogenése, Evry, France. sonia.stefanovic@inserm.fr
Abstract:
OCT4 encoded by pou5f1 is one of the most ancient and early transcription factors identified in the embryo. It has been longwise recognized as a gatekeeper for pluripotency of embryonic stem (ES) cell. Uncovered twenty years ago, its fame was built up from its key role in maintaining embryonic stem cell pluripotency in 1998. Since, OCT4 was reported to also instruct stem cell fate through a gene dosage effect. It reached recently a novel glorious hit with its master role in reprogramming somatic cells.
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