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Published on: September 9, 2011
Risedronate-induced arthritis
Oya Umit Yemisci1, Seniz Akcay Yalbuzdag, Metin Karatas
1Department of Physical Medicine and Rehabilitation, Baskent University, Ankara, Turkey. oyaumit@hotmail.com
Summary
A patient developed acute arthritis after taking risedronate for osteoporosis. Symptoms resolved with rest but returned upon drug re-administration, suggesting a potential side effect of bisphosphonates.
Area of Science:
- Rheumatology
- Pharmacology
Background:
- Bisphosphonates are a primary treatment for osteoporosis.
- Risedronate is a commonly prescribed oral bisphosphonate medication.
Observation:
- A 58-year-old woman with osteoporosis experienced acute arthritis.
- Symptoms appeared 48 hours after her second dose of weekly oral risedronate.
- Elevated serum acute-phase reactants were noted, with no signs of rheumatoid or seronegative arthritis.
Findings:
- The patient's arthritis symptoms resolved with rest.
- Arthritis recurred upon a subsequent rechallenge with risedronate.
- This suggests a potential adverse reaction to risedronate.
Implications:
- Aminobisphosphonates may possess proinflammatory properties.
- Physicians should consider drug-induced arthritis as a potential side effect of risedronate.
- Awareness of this adverse effect is crucial given the widespread use of bisphosphonates.
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