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Therapeutic hotline: Ulcerative lichen planus--treatment challenges
Carmen Sălăvăstru1, George-Sorin Tiplica
12nd Clinic of Dermatology, Colentina Clinical Hospital, Bucharest, Romania. galati1968@yahoo.com
Dermatologic Therapy
|April 27, 2010
Summary
Topical tacrolimus ointment effectively treated a rare case of ulcerative lichen planus of the sole. This treatment rapidly reduced pain and healed plantar ulcers, restoring patient mobility.
Area of Science:
- Dermatology
- Immunology
Background:
- Ulcerative lichen planus (ULP) is a rare variant of lichen planus.
- Plantar ULP presents as painful, erosive ulcers, significantly impacting mobility.
- ULP is notoriously resistant to conventional treatments.
Observation:
- A 77-year-old woman presented with a 24-month history of debilitating, relapsing plantar ulcers.
- The patient experienced severe pain and near-complete loss of ambulation due to the foot lesions.
Findings:
- Topical tacrolimus ointment 0.1% (twice daily) was administered.
- Complete pain resolution occurred within one week.
- Ulcers showed 95% epithelialization after four weeks of treatment.
- No adverse secondary effects were observed during therapy.
Implications:
- Topical tacrolimus offers a promising therapeutic option for recalcitrant plantar ulcerative lichen planus.
- This treatment can rapidly alleviate pain and restore function in affected individuals.
- Further research into topical immunosuppressants for ULP is warranted.
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