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Updated: Jun 13, 2026

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

The Scottish Structural Proteomics Facility: targets, methods and outputs.

Muse Oke¹, Lester G Carter, Kenneth A Johnson

¹Biomedical Sciences Research Complex, University of St Andrews, St Andrews, KY16 9ST, UK.

Journal of Structural and Functional Genomics

|April 27, 2010

Summary

This summary is machine-generated.

The Scottish Structural Proteomics Facility successfully determined over 40 protein structures using high-throughput methods. This achievement highlights the balance between automation and expertise in structural biology research.

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Area of Science:

Structural Biology
Biochemistry
Proteomics

Background:

The Scottish Structural Proteomics Facility was established to advance high-throughput protein structure determination.
Previous methods for structure determination were not sufficiently high-throughput for the growing need for structural data.

Purpose of the Study:

To report on the development and outcomes of a laboratory-scale, high-throughput approach to protein structure determination.
To reflect on the efficiency, challenges, and impact of automated structural biology pipelines.

Main Methods:

Development of a laboratory-scale, high-throughput pipeline for protein structure determination.
Determination of over 40 protein structures.
Detailed reporting of experimental methods and deposition of structural data.

Main Results:

Successful determination of over 40 protein structures within a 5-year period.
Publication of ten peer-reviewed papers reporting structural data.
Generation of structural data exceeding the capacity for immediate in-depth analysis and publication.

Conclusions:

The facility demonstrated a successful high-throughput approach to protein structure determination.
Automation is valuable but requires significant scientific and technical expertise.
The project's impact is maximized by sharing experimental details and deposited structures for further biological investigation.