Inflammatory markers and physical performance among nonagenarians.

Area of Science:

• Gerontology
• Immunology
• Biomedical Science

Background:

• Inflammation is increasingly recognized as a factor in aging and disability.
• Limited data exists on inflammation's role in muscle weakness and functional decline in the very old.
• This study investigates inflammatory markers in nonagenarians.

Purpose of the Study:

• To examine the association between inflammatory markers and physical performance in nonagenarians.
• To determine if inflammation impacts handgrip strength, Barthel Index, and chair stand performance.

Main Methods:

• A population-based sample of 262 nonagenarians (197 women, 65 men) aged 90 years.
• Physical performance assessed using the Barthel Index, chair stand test, and handgrip strength.
• Plasma levels of interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1Ra), and C-reactive protein (CRP) were measured.

Main Results:

• High levels of CRP, IL-6, and IL-1Ra were associated with poorer handgrip strength.
• High levels of CRP, IL-6, and IL-1Ra were associated with a worse Barthel Index score.
• No significant association was found between inflammatory markers and chair stand performance.

Conclusions:

• Elevated inflammatory markers are associated with reduced handgrip strength and functional capacity in nonagenarians.
• Inflammation may contribute to muscle weakness and disability in advanced age.
• The chair stand test did not show a significant association with inflammatory markers in this cohort.