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Published on: August 16, 2018
Sesquiterpene lactones from Inula oculus-christi
Mahmoud Mosaddegh1, Maryam Hamzeloo Moghadam, Saeedeh Ghafari
1Traditional Medicine and Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. mmosaddegh@itmrc.org
Natural Product Communications
|May 4, 2010
Summary
Researchers isolated three sesquiterpene lactones from Inula oculus-christi L. extract, with ergolide and gaillardin showing significant cytotoxic activity against cancer cell lines.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Inula oculus-christi L. is a plant species within the Compositae family.
- Sesquiterpene lactones are a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize sesquiterpene lactones from Inula oculus-christi L.
- To evaluate the in vitro cytotoxic activity of the isolated compounds.
Main Methods:
- Chromatographic separation of plant extract.
- Spectroscopic data analysis (NMR, MS) for structure elucidation.
- X-ray crystallography for definitive structure determination.
- In vitro cytotoxicity assays against MDBK, MCF7, and WEHI164 cell lines.
Main Results:
- Isolation of three sesquiterpene lactones: ergolide, gaillardin, and pulchellin C.
- Ergolide and pulchellin C were reported for the first time from this species.
- Ergolide and gaillardin demonstrated significantly lower IC50 values compared to pulchellin C in cytotoxicity assays (p<0.001).
Conclusions:
- Inula oculus-christi L. is a source of bioactive sesquiterpene lactones.
- Ergolide and gaillardin possess notable in vitro cytotoxic properties, suggesting potential therapeutic applications.
