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Related Concept Videos

Integration of Synaptic Events01:28

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of specific...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...

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Related Experiment Video

Updated: Jun 13, 2026

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons
14:37

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons

Published on: September 30, 2014

Presynaptic miniature GABAergic currents in developing interneurons.

Federico F Trigo1, Brice Bouhours, Philippe Rostaing

  • 1CNRS, Unité 8118, Université Paris Descartes, 75006 Paris, France.

Neuron
|May 4, 2010
PubMed
Summary
This summary is machine-generated.

Researchers discovered "preminis," a new type of miniature synaptic current. These currents enhance neurotransmitter release in developing cerebellar networks, potentially guiding synapse formation.

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Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
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Related Experiment Videos

Last Updated: Jun 13, 2026

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons
14:37

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Published on: September 30, 2014

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

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Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
09:09

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Developmental Neurobiology

Background:

  • Miniature synaptic currents (mPSCs) typically reflect spontaneous neurotransmitter release.
  • The precise function and regulation of mPSCs in central nervous system development are not fully understood.
  • GABAergic interneurons in the cerebellum play critical roles in network formation and function.

Purpose of the Study:

  • To identify and characterize novel types of miniature synaptic currents.
  • To investigate the mechanisms and functional implications of these currents in developing cerebellar circuits.
  • To explore the potential role of these currents in guiding synaptic network formation.

Main Methods:

  • Electrophysiological recordings in developing cerebellar slices.
  • Pharmacological manipulation to assess receptor involvement.
  • Analysis of synaptic current properties, including frequency and amplitude.
  • Investigation of the impact of membrane potential on current generation.

Main Results:

  • A new class of miniature currents, termed "preminis," was identified, arising from autocrine activation of axonal receptors.
  • Preminis were prominent in developing GABAergic synapses of cerebellar interneurons.
  • Premini frequency, but not amplitude, was significantly enhanced by subthreshold membrane depolarization.
  • This suggests a feedback mechanism where preminis regulate neurotransmitter release.

Conclusions:

  • Preminis represent a distinct form of synaptic activity mediated by autocrine signaling.
  • Their activity-dependent regulation suggests a role in activity-dependent synapse refinement.
  • Preminis may actively guide the formation and maturation of cerebellar interneuron networks during development.