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Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
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[Trefoil factor: from laboratory to clinic].

Ting-Yi Du1, Yong Zhang, Yun Zhang

  • 1Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming Yunnan 650223, China. timkally@hotmail.com

Dong Wu Xue Yan Jiu = Zoological Research
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Trefoil factor (TFF) peptides are crucial for mucosal protection and wound healing. However, their aberrant expression in tumors suggests a role in cancer progression, necessitating further research into their mechanisms.

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Last Updated: Jun 13, 2026

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
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Published on: December 25, 2021

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Trefoil factor (TFF) peptides, characterized by conserved trefoil domains, exhibit heat and enzymatic resistance.
  • Mammalian TFFs (TFF1-3) are expressed in the gastrointestinal and airway systems, playing roles in mucosal protection and wound healing.
  • Aberrant TFF expression in malignant tissues correlates with tumor genesis, metastasis, and invasion, indicating a potential role in oncogenic responses.

Purpose of the Study:

  • To elucidate the complex biological functions and molecular mechanisms of TFF peptides.
  • To investigate the role of TFFs in both physiological processes and oncogenesis.
  • To explore the significance of TFF-crystallin complexes in understanding TFF functions.

Main Methods:

  • Review of existing literature on TFF family peptides.
  • Analysis of TFF expression patterns in physiological and pathological conditions.
  • Exploration of signaling pathways and protein interactions involving TFFs.

Main Results:

  • TFFs are involved in mucosal protection and wound healing under physiological conditions.
  • TFFs are widely expressed in malignant tissues and linked to tumor progression.
  • TFFs can exert functions through single-chain signaling or complex formation with other proteins.
  • The discovery of TFF-crystallin complexes offers new insights into TFF mechanisms.

Conclusions:

  • TFFs represent a potential common mediator in oncogenic responses.
  • Understanding TFFs' precise actions and molecular mechanisms remains a critical research challenge.
  • Further investigation into TFFs, particularly their complexes, is vital for clinical applications in mucosal repair and cancer diagnostics/therapeutics.