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Updated: Jun 13, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
The addition of a hydroxyapatite coating changes the immediate postoperative stability of a plasma-sprayed femoral
Amos Race1, Christopher D Heffernan, Peter F Sharkey
1Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA.
Abstract:
Nonbiologic and mechanical effects of hydroxyapatite coatings have received little evaluation. Hydroxyapatite coatings give porous metal the appearance of decreased roughness. We hypothesized that this apparent decrease in surface roughness would result in diminished initial implant stability. We measured the initial stability of titanium plasma sprayed press-fit femoral stems with and without HA. Stems were implanted into cadaver and synthetic femora and subjected to aggressive stair-climbing loads. Migrations (retroversion and subsidence) and cyclic motions were recorded. Hydroxyapatite coating significantly reduced retroversion (P = .0007) and cyclic subsidence (P = .0086). Scanning electron microscopy imaging revealed that HA coating appeared to have reduced roughness on a millimeter scale but increased roughness on a micrometer scale. We concluded that HA coating improves initial stability through mechanical means, before biological action.

