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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Computed Tomography01:10

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Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
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Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.

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Updated: Jun 13, 2026

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
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Published on: October 17, 2016

Common path optical coherence tomography with fibre bundle probe.

J-H Han1, X Liu, C G Song

  • 1Department of Electrical and Computer Engineering, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.

Electronics Letters
|May 11, 2010
PubMed
Summary
This summary is machine-generated.

A novel common path optical coherence tomography system uses a fiber optic bundle probe for intraoperative imaging. Its design enables submillimeter probe integration into surgical tools, eliminating distal moving parts.

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Last Updated: Jun 13, 2026

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Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology

Background:

  • Optical Coherence Tomography (OCT) is a valuable non-invasive imaging modality.
  • Current OCT probes often require complex distal mechanisms, limiting miniaturization and integration.

Purpose of the Study:

  • To demonstrate a simple common path OCT system with a fiber optic bundle probe.
  • To enable integration of OCT probes into surgical tools for intraoperative imaging.

Main Methods:

  • A common path OCT system was designed using a fiber optic bundle as the probe.
  • Mechanical lateral scans were performed externally at the proximal end of the fiber bundle.
  • This design eliminates the need for distal moving parts within the probe.

Main Results:

  • The system achieved submillimeter probe size, facilitating integration.
  • Preliminary imaging of phantom samples was performed.
  • Axial and lateral resolutions of the system were reported.

Conclusions:

  • The developed common path OCT system offers a simplified probe design.
  • Its small size and lack of distal moving parts are advantageous for surgical tool integration.
  • This technology holds potential for real-time intraoperative imaging applications.