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Updated: Jun 13, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
DNA-based hybrid catalysts for asymmetric organic synthesis
Soyoung Park1, Hiroshi Sugiyama
1Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Abstract:
Stereoselective hybrid systems based on metal-assisted catalysis with a chiral biomacromolecule form an attractive research area for the synthesis of enantiomerically pure compounds. Although various methods are available for this purpose, most rely on the use of enzymes, proteins, or RNA. The application of DNA-based hybrid catalysts for enantioselective synthesis emerged only a few years ago. DNA-based hybrid catalysts have been self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies and have demonstrated high stereoselectivity and rate enhancement in Lewis acid catalyzed reactions, such as Diels-Alder, Michael addition, and Friedel-Crafts reactions. For these reactions, cheap and commercially available salmon testes DNA has generally been used. In this Minireview, we summarize recent developments in the area of asymmetric catalysis with DNA-based hybrid catalysts.
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